The Baum Group - Publications

Selected Collagen Publications:

Roth, J., C.L. Hoop, J.K. Williams, R. Hayes, and J. Baum. "Depletion of Glycosaminoglycans Decreases Contact Stiffness of Single Collagen I Fibrils in Aqueous Solution." bioRxiv. (2020). doi: 10.1101/2020.02.07.935932

Hoop, C.L., J. Zhu, S. Bhattacharya, C.A. Tobita, S.E. Radford, and J. Baum. "Collagen I Weakly Interacts with the β-sheets of β2-Microglobulin and Enhances Conformational Exchange to Induce Amyloid Formation." J. Am. Chem. Soc. 142:1321-1331 (2020). doi: 10.1021/jacs.9b10421

Hoop, C.L., A.P. Kemraj, B. Wang, S. Gahlawat, M. Godesky, J. Zhu, H.R. Warren, D.A. Case, D.I. Shreiber, and J. Baum. "Molecular Underpinnings of Integrin Binding to Collagen-Mimetic Peptides Containing Vascular Ehlers-Danlos Syndrome-Associated Substitutions." J. Biol. Chem. 294:14442-14453 (2019). doi: 10.1074/jbc.RA119.009685

Benseny-Cases, N., T.K. Karamanos, C.L. Hoop, J. Baum, and S.E. Radford. "Extracelllular Matrix Components Modulate Different Stages of β2-Microglobulin Amyloid Formation." J. Biol. Chem. 294:9392-9401 (2019). doi: 10.1074/jbc.RA119.008300

Zhu, J., C.L. Hoop, D.A. Case, and J. Baum. "Cryptic Binding Sites Become Accessible Through Surface Reconstruction of the Type I Collagen Fibril." Scientific Reports. 8:16646 (2018). doi:10.1038/s41598-018-34616-z

Nunes, A.M., C.A.S.A. Minetti, D.P. Remeta, and J. Baum. "Magnesium Activates Microsecond Dynamics to Regulate Integrin-Collagen Recognition." Structure. 26:1080-1090 (2018). doi:10.1016/j.str.2018.05.010

Hoop, C.L., J. Zhu, A.M. Nunes, D.A. Case, and J. Baum. "Revealing Accessibility of Cryptic Protein Binding Sites within the Functional Collagen Fibril." Biomolecules. 7:76 (2017). doi:10.3390/biom7040076

An, B., S.-W. Chang, C. Hoop, J. Baum, M.J. Buehler, and D.L. Kaplan. “Structural Insights into the Glycine Pair Motifs in Type III Collagen.” ACS Biomater. Sci. Eng. 3:269–278 (2017). doi:10.1021/acsbiomaterials.6b00512

Nunes, A.M., J. Zhu, J. Jezioro, C.A.S.A. Minetti, D.P. Remeta, R.W. Farndale, S.W. Hamaia, and J. Baum. “Intrinsic Local Destabilization of the C-Terminus Predisposes Integrin α1 I Domain to a Conformational Switch Induced by Collagen Binding.” Protein Science. 25:1672–1681 (2016). doi:10.1002/pro.2972

Fu, I., D.A. Case, and J. Baum. “Dynamic Water-Mediated Hydrogen Bonding in a Collagen Model Peptide.” Biochemistry. 54:6029–6037 (2015). doi:10.1021/acs.biochem.5b00622

Xiao, J., X. Sun, B. Madhan, B. Brodsky, and J. Baum. “NMR Studies Demonstrate a Unique AAB Composition and Chain Register for a Heterotrimeric Type IV Collagen Model Peptide Containing a Natural Interruption Site.” J. Biol. Chem. 290:24201–24209 (2015). doi:10.1074/jbc.M115.654871

Xiao, J., Z. Yang, X. Sun, R. Addabbo, and J. Baum. “Local Amino Acid Sequence Patterns Dominate the Heterogeneous Phenotype for the Collagen Connective Tissue Disease Osteogenesis Imperfecta Resulting from Gly Mutations.” J. Struct. Biol. 192:127–137 (2015). doi:10.1016/j.jsb.2015.05.002

Parmar, A.S., A.M. Nunes, J. Baum, and B. Brodsky. “A Peptide Study of the Relationship Between the Collagen Triple-Helix and Amyloid.” Biopolymers. 97:795–806 (2012). doi:10.1002/bip.22070

Selected α/β-Synuclein Publications:

Stoeber, J., J.K. Williams, P.V. Moghe, and J. Baum. "Tannic Acid Inhibits a-Synuclein Amyloid Fibril Formation via Binding to the Monomer N-terminal Domain." bioRxiv. (2021). doi:10.1101/2021.05.26.445860

Yang, X., B. Wang, C.L. Hoop, J.K. Williams, and J. Baum. "NMR Unveils an N-terminal Interaction Interface on Acetylated-α-synuclein Monomers for Recruitment to Fibrils." Proc. Natl. Acad. Sci. USA. (2021). doi:10.1073/pnas.2017452118

Zhao, N., X. Yang, H.R. Calvelli, Y. Cao, N.L. Francis, R.A. Chmielowski, L.B. Joseph, Z.P. Pang, K.E. Uhrich, J. Baum, and P.V. Moghe. "Antioxidant Nanoparticles for Concerted Inhibition of α-Synuclein Fibrillization, and Attenuation of Microglial Intracellular Aggregation and Activation." Frontiers in Bioengineering and Biotechnology. 8: 112 (2020). doi:10.3389/fbioe.2020.00112

Zhang, J., E.S. Park, H.-J. Park, R. Yan, M. Grudniewska, X. Zhang, S. Oh, X. Yang, J. Baum, and M.M. Mouradian. "Apoptosis Signal Regulating Kinase 1 Deletion Mitigates the α-Synuclein Pre-formed Fibril Propagation Model in Mice." Neurobiology of Aging. 85: 49–57 (2020). doi:10.1016/j.neurobiolaging.2019.09.012

Yang, X., J.K. Williams, R. Yan, M. M. Mouradian, and J. Baum. "Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity." Scientific Reports9, 17579 (2019). doi:10.1038/s41598-019-54063-8

Williams, J.K., X. Yang, and J. Baum. "Interactions between the Intrinsically Disordered Proteins β-Synuclein and α-Synuclein." Proteomics. 1800109 (2018). doi:10.1002/pmic.201800109

Williams, J.K., X. Yang, T.B. Atieh, M.P. Olson, S.D. Khare, and J. Baum. "Multi-Pronged Interactions Underlie Inhibition of α-Synuclein Aggregation by β-Synuclein." J. Mol. Biol. 430: 2360-2371 (2018). doi:10.1016/j.jmb.2018.05.024

Moriarty, G.M., M.P. Olson, T.B. Atieh, M.K. Janowska, S.D. Khare, and J. Baum. “A pH-Dependent Switch Promotes β-Synuclein Fibril Formation via Glutamate Residues.” J. Biol. Chem. 292:16368–16379 (2017). doi:10.1074/jbc.M117.780528

Bennett, N.K., R. Chmielowski, D.S. Abdelhamid, J.J. Faig, N. Francis, J. Baum, Z.P. Pang, K.E. Uhrich, and P.V. Moghe. “Polymer Brain-Nanotherapeutics for Multipronged Inhibition of Microglial α-Synuclein Aggregation, Activation, and Neurotoxicity.” Biomaterials. 111:179–189 (2016). doi:10.1016/j.biomaterials.2016.10.001

Janowska, M.K. and J. Baum. “Intermolecular Paramagnetic Relaxation Enhancement (PRE) Studies of Transient Complexes in Intrinsically Disordered Proteins.” D. Eliezer (Ed.), Protein Amyloid Aggregation: Methods and Protocols, Methods in Molecular Biology, 1345:45–53 (2016). doi:10.1007/978-1-4939-2978-8_3

Janowska, M.K., K.-P. Wu, and J. Baum. “Unveiling Transient Protein-Protein Interactions that Modulate Inhibition of alpha-Synuclein Aggregation by beta-Synuclein, a Pre-Synaptic Protein that co-Localizes with alpha-Synuclein.” Sci. Rep. 5:15164 (2015). doi:10.1038/srep15164

Janowska, M.K. and J. Baum. “The Loss of Inhibitory C-Terminal Conformations in Disease Associated P123H β-synuclein.” Protein Science. 25:286–294 (2015). doi:10.1002/pro.2798

Moriarty, G.M., C.A.S.A. Minetti, D.P. Remeta, and J. Baum. “A Revised Picture of the Cu(II)−α-Synuclein Complex: The Role of N-Terminal Acetylation.” Biochemistry. 53:2815–2817 (2014). doi:10.1021/bi5003025

Kang, L., M.K. Janowska, G.M. Moriarty, and J. Baum. “Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence.” PLoS ONE. 8:e75018–10 (2013). doi:10.1371/journal.pone.0075018

Moriarty, G.M., M.K. Janowska, L. Kang, and J. Baum. “Exploring the Accessible Conformations of N-Terminal Acetylated α-Synuclein.” FEBS Letters. 587:1128–1138 (2013). doi:10.1016/j.febslet.2013.02.049

Kim, S., K.-P. Wu, and J. Baum. “Fast Hydrogen Exchange Affects 15N Relaxation Measurements in Intrinsically Disordered Proteins.” J. Biomol. NMR. 55:249–256 (2013). doi:10.1007/s10858-013-9706-1

Narayanan, C., D.S. Weinstock, K.-P. Wu, J. Baum, and R.M. Levy. “Investigation of the Polymeric Properties of α-Synuclein and Comparison with NMR Experiments: A Replica Exchange Molecular Dynamics Study.” J. Chem. Theory Comput. 8:3929–3942 (2012). doi:10.1021/ct300241t

Kang, L., G.M. Moriarty, L.A. Woods, A.E. Ashcroft, S.E. Radford, and J. Baum. “N-terminal Acetylation of α-synuclein Induces Increased Transient Helical Propensity and Decreased Aggregation Rates in the Intrinsically Disordered Monomer.” Protein Science. 21:911–917 (2012). doi:10.1002/pro.2088