The Baum Group studies protein-protein interaction and protein aggregation through biochemical and biophysical techniques, including Nuclear Magnetic Resonance.
October 2019: Our recent paper "Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity" has been accepted in Scientific Reports! Great work, Snow and Jon!
October 2019: Our collaborative work with the lab of Adam Gormley and others is now in Press at Macromolecules: "PET-RAFT and SAXS: High throughput tools to study compactness and flexibility of single-chain polymer nanoparticles." Good work, everyone!
October 2019: Check out our recent work "Collagen I weakly interacts with the β-sheets of β2-microglobulin and enhaces conformational exchange to induce amyloid formation" available as a pre-print on bioRxiv!
September 2019: Our recent collaboration with the lab of Maral Mouradian has been published in Neurobiology of Aging: "Apoptosis signaling regulating kinase 1 deletion mitigates the α-synuclein pre-formed fibril propagation model in mice".
August 2019: Our new paper "Molecular underpinnings of integrin binding to collagen mimetic peptides containing vascular Ehlers-Danlos syndrome-associated substitutions" is now in Press at J. Biol. Chem. Nice work everyone!
April 2019: Our new paper with Sheena Radford "Extracellular matrix components modulate different stages in β2-microglobulin amyloid formation" is now in Press at J. Biol. Chem.
April 2019: Congratulations to Jonathan Stoeber who has been accorded an Honorable Mention in the 2019 National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP) competition, a significant national achievement!
January 2019: Our recent work on "Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity" is available as a pre-print on bioRxiv. Check it out!
January 2019: We welcome our new Laboratory Technician, Scott Taylor!
January 2019: Welcome to Caitlyn Tobita and Ben Ashamole, who have joined the group as graduate students!
November 2018: Our new paper "Cryptic binding sites become accessible through surface reconstruction of the type I collagen fibril" is now in Press at Scientific Reports. Nice work, Jie and Cody!
October 2018: The Baum Lab is now located in the brand new Chemistry & Chemical Biology Building!
October 2018: Jie has successfully defended her PhD! Congratulations, Jie!!
September 2018: Our review on the "Interactions between the Intrinsically Disordered Proteins β-Synuclein and α-Synuclein" is now In Press at Proteomics. Nice work Jon and Snow!
May 2018: Ana's paper "Magnesium Activates Microsecond Dynamics to Regulate Integrin-Collagen Recognition" is In Press at Structure. Nice job Ana!
May 2018: "Multi-Pronged Interactions Underlie Inhibition of α-Synuclein Aggregation by β-Synuclein" is now In Press at J. Mol. Biol. Good work everyone!
March 2018: Dr. Baifan Wang has joined the group as a Postdoctoral Associate. Welcome!
January 2018: Jonathan Stoeber joins the group as a new graduate student. Welcome!