Research Highlights

Nondestructive Real-Time Monitoring of Enhanced Stem Cell Differentiation Using a Graphene-Au Hybrid Nanoelectrode Array

kibum article4 abf4eStem cells have attracted increasing research interest in the field of regenerative medicine because of their unique ability to differentiate into multiple cell lineages. However, controlling stem cell differentiation efficiently and improving the current destructive characterization methods for monitoring stem cell differentiation are the critical issues.

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Overcoming Chemoresistance in Cancer Using Nanotechnology-based Drug Delivery

kibum article 3 000b0Chemoresistance is a major challenge facing the effective treatment of cancers. To overcome resistance to chemotherapy, microRNA (miRNA), which are short (20−22 nucleotides) noncoding RNA molecules, has shown to be an attractive strategy. A growing body of evidence shows that modulation of miRNA levels in cancer can mitigate the development and progression of cancer.  

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A Biodegradable Hybrid Inorganic Nanoscaffold for Advanced Stem Cell Therapy

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Considering the intrinsically limited regenerative capability of the central nervous system (CNS) and the complex inhibitory microenvironment of injured spinal cord, developing effective therapeutics for CNS diseases and injuries [e.g., Parkinson disease and spinal cord injury (SCI)] has been challenging. To this end, stem cell therapy can provide a promising solution. Neural stem cells can differentiate into neurons and restore the damaged neuronal circuits. Additionally, stem cells modulate the inhibitory microenvironment at the site of CNS disease and injury through the secretion of trophic factors. Nevertheless, the low survival rate and incomplete differentiation control of stem cells in vivo are critical barriers for the full realization of stem cell therapy potential. As such, there is an urgent need to develop an innovative approach to enhance stem cell transplantation and to control stem cell fate precisely.

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Rutgers-led Research Could Revolutionize Nuclear Waste Reprocessing and Save Money

 MolecularTraps2Fig300 f1590Seeking a better way to capture radioactive iodides in spent nuclear reactor fuel, Rutgers–New Brunswick scientists have developed an extremely efficient “molecular trap” that can be recycled and reused.

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Computation-guided design of a stimulus-responsive multi-enzyme supramolecular assembly.

Kharehighlight1 The construction of stimulus-responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multi-enzyme assemblies (metabolons), provides an attractive avenue for efficient and spatio-temporally controllable one-pot biotransformations.

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Sustainable, Nanocarbon-Based Catalysts for Production of Hydrogen (a Clean, Renewable Fuel) from Water (a Sustainable Source) at All pH Values

In the face of the growing demand of energy worldwide and the unabated negative environmental impacts of fossil fuels, alternative and greener energy sources are critically important.

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Sugar-based Amphiphilic Polymers for Biomedical Applications: from Nanocarrier to Therapeutic

The research of Professor Kathryn Uhrich has designed and examined a library of sugar-based amphiphilic polymers (SBAPs) which demonstrate promise in diverse biomedical applications, ranging from nanoscale drug delivery vehicles to cardiovascular therapeutics.

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Poly(anhydride-esters) Comprised Exclusively of Naturally-occurring Antimicrobials and EDTA: Antioxidant and Antibacterial Activities

Naturally derived antioxidants and antimicrobials (eugenol, carvacrol, thymol) were chemically incorporated as pendant groups into biodegradable poly(anhydride-esters) composed of ethylenediaminetetraacetic acid as backbone, and hydrolytic degradation of these polymers yielded the free compounds which exhibited bioactivity.

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NanoScript: A Nanoparticle-Based Artificial Transcription Factor for Effective Gene Regulation

Transcription factor (TF) proteins are master regulators of transcriptional activity and gene expression.

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LMOFs for Explosive Detection

Luminescent metal-organic frameworks (LMOFs) are a sub-class of metal organic framework materials that possess interesting and useful optical emission properties, making them both fundamentally important and technologically relevant for practical applications.

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Hepatitis C Virus (HCV)

The research of Associate Professor Joseph Marcotrigiano has isolated and examined an outer region of hepatitis C that enables the virus to evade the body’s natural immune system response, which causes persistent, chronic infection.

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Graphene-Nanofiber Hybrid Scaffolds Guide Stem Cell Differentation into Oligodendrocytes

Damage to the central nervous system (CNS) can cause severe neurological deficits, thus requiring innovative strategies to promote functional recovery.

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Cationic Amphiphilic Macromolecule (CAM)-lipid Complexes for Efficient siRNA Gene Silencing

Cationic amphiphilic macromolecules were complexed with liposomal delivery systems to encapsulate and efficiently deliver siRNA in response to a decrease in endosomal pH and silence target genes with minimal cytotoxicity.

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Thinking about Chemical Reactivity in Colloids, from Micelles to Emulsions

Surfactants of many kinds, simple soaps, phospho- glycol- and proteo- lipids spontaneously self-assemble to form transparent thermodynamically stable solutions of association colloids, e.g., micelles, vesicles and microemulsions.

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Supplementing NanoScript with Epigenetic Modulators for Enhanced Gene Transcription

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Stem cell-based therapies and cellular reprogramming holds immense potential for regenerative medicine

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Rare-Earth-Free LED Phosphors

Professor Jing Li's recent development of rare-earth-free phosphors was featured at the American Chemical Society (ACS) national meeting on August 19, 2015.

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The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA

nature18622 pf4 croppedRibonucleic acid (RNA) is central to gene expression. RNA stabilty is determined largely by the chemical nature of the RNA 5' end.

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NanoScript Can Activate or Deactivate Specific Genes for Non-Viral Stem Cell Differentiation

While stem cell therapies appear very promising, there is a critical gap that exists between our current knowledge and the practical application of stem cell therapies, and as a result, there is not a single stem cell therapy that is approved by the FDA!  

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Design, Synthesis, and Characterization of Graphene-Nanoparticle Hybrid Materials for Bioapplications

Graphene is composed of single-atom thick sheets of carbon atoms that are arranged in a perfect two-dimensional honeycomb lattice.

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Nanoelectrochemistry for Detection of Neurotransmitters in Dopaminergic Neuron Differentiation

Stem-cell-based therapy has emerged as a promising therapeutic strategy for regenerative medicine due the ability of stem cells to differentiation into any given cell type.

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