Pushing the Boundaries of Chemical Identification with Mass Spectrometry
Mass spectrometry (MS) has emerged as a powerful tool with a myriad of different applications in biology, chemistry, and physics, but also in clinical medicine and even space exploration. It is used to determine the molecular weight of compounds by separating molecular ions based on their mass and charge. MS has distinguished itself as an indispensable tool for the characterization of a plethora of small molecules including structural elucidations from known to unknown compounds. Furthermore, it’s also been used extensively in all the arena of “Omics” for biomarker discovery pertaining to life-threatening diseases and in precision medicine. The development of two soft ionization techniques capable of ionizing proteins – electrospray ionization, matrix-assisted laser desorption ionization and quite recently Ion-mobility MS has revolutionized to study mega protein structures. Due to its speed and sensitivity, mass spectrometry has also played a pivotal role in many phases of drug discovery, drug reaction optimization, structural analysis of library products, and the evaluation of library compound quality.
In my talk, I will present a few examples and deduce how AICF- MS instruments can benefit the CCB and non- CCB communities.
~Coffee/tea will be served prior to the lecture~