Catalytic and mechanistic studies on hydrocarbon C-H borylation by iridium complexes
Dipyridylarylmethane ligands undergo directed C-H metalation to give iridium complexes which are highly active catalysts for alkane C-H borylation. Using modular synthetic routes, we show that ligand substitution plays a major role in determining catalyst activity and speciation. Terminal-selective C-H borylation of aliphatic hydrocarbons proceeds through a catalytic transformation whose resting state evolves through a sequence of three catalyst species which differ by the degree of catalyst borylation. Applications to the derivatization of other substrate classes are also explored.
Hosted by Professor Alan Goldman