BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:b560ae31dbd5b9a0459099cd00d642c7 CATEGORIES:Colloquium CREATED:20221130T150833 SUMMARY:Professor Dingchang Lin, Johns Hopkins University LOCATION:CCB Auditorium (Room 1303) DESCRIPTION:
R esolving neuronal activity in space and time is a long-sought capability in neuroscience, which is, however, still hard to achieve using existing tech nologies. In this talk, I will share with the audience our strategies towar d this goal via innovations at the device and molecular levels. In the firs t part of my talk, I will start by introducing our recent development of ul tra flexible neural probes that exhibit extraordinary biocompatibility and the capability of chronic single-unit recording. I will then share our new implantation modality that can nonlinearly deploy our probes into the brain with minimal surgical lesions. The modality allows conformal coverage of n onlinear brain structures or circuits using microelectrode arrays and there fore enables high-density neural recording along designated trajectories. I n the second part of my talk, I will switch to our recent endeavors in deve loping protein “ticker tapes” for the longitudinal recording of cellular ev ents. The technology exploits activity-dependent transcriptional activation to convert neural activities into fluorescently readable signals in cells. The signals can be recorded by protein nanodevices genetically encoded in individual cells for retrospective retrieval. This strategy provides an att ainable path toward organ-wide longitudinal mapping at the single-cell leve l.
Hosted by Professor Zheng Shi
~Coffee/t ea will be served prior to the lecture~
X-ALT-DESC;FMTTYPE=text/html:Electronic and molecular approaches for neural recording: deciphering the brain in space and time
Resolving neuronal activity in space and time is a long-sought capability in neuroscience, which is, however, still hard to achieve using existing technologies. In this talk, I will share with the a udience our strategies toward this goal via innovations at the device and m olecular levels. In the first part of my talk, I will start by introducing our recent development of ultra flexible neural probes that exhibit extraor dinary biocompatibility and the capability of chronic single-unit recording . I will then share our new implantation modality that can nonlinearly depl oy our probes into the brain with minimal surgical lesions. The modality al lows conformal coverage of nonlinear brain structures or circuits using mic roelectrode arrays and therefore enables high-density neural recording alon g designated trajectories. In the second part of my talk, I will switch to our recent endeavors in developing protein “ticker tapes” for the longitudi nal recording of cellular events. The technology exploits activity-dependen t transcriptional activation to convert neural activities into fluorescentl y readable signals in cells. The signals can be recorded by protein nanodev ices genetically encoded in individual cells for retrospective retrieval. T his strategy provides an attainable path toward organ-wide longitudinal map ping at the single-cell level.
Hosted by Professor Zheng Shi
~Coffee/tea will be served prior to the lectur e~
DTSTAMP:20240328T212550 DTSTART:20230131T160000 DTEND:20230131T170000 SEQUENCE:0 TRANSP:OPAQUE END:VEVENT END:VCALENDAR