BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:89fd6bba7f1d8c5856ce9b26a875aee9 CATEGORIES:Colloquium CREATED:20200723T155025 SUMMARY:Professor Medha Pathak, University of California at Irvine DESCRIPTION:\n"Watching cellular mechanotransduction: Piezo1 in neural stem cell fate"\ nA major unanswered question in biology is how mechanical forces are genera ted, detected and transduced by cells to impact biochemical and genetic pro grams. Our work is aimed at uncovering the mechanical principles at play in cells and tissues using novel molecular, imaging and bioengineering tools. Here we present insights gleaned from non-invasive approaches to measure a nd manipulate mechanical cues in native cellular conditions. We find that t he mechanically-activated ion channel Piezo1 transduces cell-generated trac tion forces to regulate lineage choice of neural stem cells. Our studies pr ovide quantitative and mechanistic insights on the role of mechanical force s in cellular dynamics.\n \nMeeting Link: (https://rutgers.webex.com/rutg ers/j.php?MTID=mfe975c45aeedfc4f09bb0bf17eea5eb7)https://rutg ers.webex.com/rutgers/j.php?MTID=mfe975c45aeedfc4f09bb0bf17eea5eb7\nMee ting number: 120 154 5223\nPassword: Q9De3Px4RTM\nJoin by phone: 1-650-429- 3300\nAccess code: 120 154 5223\n X-ALT-DESC;FMTTYPE=text/html:
"Watching cellular mechanotransduction: Piezo1 in neura l stem cell fate"
A major unans wered question in biology is how mechanical forces are generated, detected and transduced by cells to impact biochemical and genetic programs. Our wor k is aimed at uncovering the mechanical principles at play in cells and tis sues using novel molecular, imaging and bioengineering tools. Here we prese nt insights gleaned from non-invasive approaches to measure and manipulate mechanical cues in native cellular conditions. We find that the mechanicall y-activated ion channel Piezo1 transduces cell-generated traction forces to regulate lineage choice of neural stem cells. Our studies provide quantita tive and mechanistic insights on the role of mechanical forces in cellular dynamics.
Meeting Link: https://rutgers.webex.co
m/rutgers/j.php?MTID=mfe975c45aeedfc4f09bb0bf17eea5eb7
Password
: Q9De3Px4RTM
Join by phone: 1-650-429-3300
Access code: 120 154 5223