BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:a9b3fa2f8a32c2748828a63e59d64562 CATEGORIES:Colloquium CREATED:20200723T154729 SUMMARY:Professor Soyoung Park, Kyoto University DESCRIPTION:
DNA as a Versatile Biomolecular Scaffold for Asymmet
ric Catalysis
DNA is one of the m ost plentiful and naturally occurring helical polymers on Earth. Recently, this ubiquitous helical polymer has gathered attention as a chiral source f or asymmetric synthesis. Since the pioneering study by Feringa in 2005, DNA -based hybrid catalysts have been applied to various key asymmetric carbon– carbon or carbon–heteroatom bond-forming reactions. Our group is exploring the potential of DNA for asymmetric catalysis. We have investigated DNA-bas ed catalysis to answer a question as: How does DNA induce selectivity in ch emical reactions? We have devised a systematic and modular strategy for the DNA hybrid catalyst based on the direct incorporation of a metal-binding l igand into the DNA strand and found the critical factors that govern c atalytic properties of DNA hybrid catalysts. This took us a new insight int o DNA metalloenzymes comprising a native DNA duplex and Cu(II) ions. Now, m y research team are working on the library of enzyme-mimic DNA hybrid catal ysts and investigating their catalytic activity with various metal ions. In this talk, I will discuss our recent progress in the development and appli cation of DNA-based hybrid catalyst for the asymmetric catalysis.
Soyoung received a B.S. degree at Ewha Womans Uni versity in 2002. She obtained her M.S. degree at KAIST under the supervisio n of Prof. Sukbok Chang in 2005. In 2009, she received a Ph.D in department of chemistry at Kyoto University under the supervision of Prof. Ryo Shinta ni and Prof. Tamio Hayashi. After JSPS postdoctoral fellowship (2010-2011), she was promoted as assistant Professor in 2012 and has continued her care er in department of chemistry at Kyoto University. Her research interests f ocus on the development and application of biohybrid materials including ar tificial metalloenzymes, fluorescent nucleosides and nucleic acid aptamers.
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ting Link: https://rutgers.webex.com/rutgers
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DNA as a Versatile Biomo lecular Scaffold for Asymmetric Catalysis
DNA is one of the most plentiful and naturally occurring helical p olymers on Earth. Recently, this ubiquitous helical polymer has gathered at tention as a chiral source for asymmetric synthesis. Since the pioneering s tudy by Feringa in 2005, DNA-based hybrid catalysts have been applied to va rious key asymmetric carbon–carbon or carbon–heteroatom bond-forming reacti ons. Our group is exploring the potential of DNA for asymmetric catalysis. We have investigated DNA-based catalysis to answer a question as: How does DNA induce selectivity in chemical reactions? We have devised a systematic and modular strategy for the DNA hybrid catalyst based on the direct incorp oration of a metal-binding ligand into the DNA strand and found the critica l factors that govern catalytic properties of DNA hybrid catalysts. Th is took us a new insight into DNA metalloenzymes comprising a native DNA du plex and Cu(II) ions. Now, my research team are working on the library of e nzyme-mimic DNA hybrid catalysts and investigating their catalytic activity with various metal ions. In this talk, I will discuss our recent progress in the development and application of DNA-based hybrid catalyst for the asy mmetric catalysis.
Soyoung received a B. S. degree at Ewha Womans University in 2002. She obtained her M.S. degree a t KAIST under the supervision of Prof. Sukbok Chang in 2005. In 2009, she r eceived a Ph.D in department of chemistry at Kyoto University under the sup ervision of Prof. Ryo Shintani and Prof. Tamio Hayashi. After JSPS postdoct oral fellowship (2010-2011), she was promoted as assistant Professor in 201 2 and has continued her career in department of chemistry at Kyoto Universi ty. Her research interests focus on the development and application of bioh ybrid materials including artificial metalloenzymes, fluorescent nucleoside s and nucleic acid aptamers.
Meeting Link: https
://rutgers.webex.com/rutgers/j.php?MTID=mfe975c45aeedfc4f09bb0bf17eea5eb7Meeting number: 120 154 5223
Password: Q9De3Px4RTM
Join by phone: 1-650-42
9-3300
Access code: 120 154 5223