BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:9208bb5955e2bafcd65ccb7443bbbc64 CATEGORIES:Colloquium CREATED:20190308T183459 SUMMARY:Professor Jonas Peters, California Institute of Technology LOCATION:CCB Auditorium DESCRIPTION:
“Synthetic Single -Site Iron Nitrogenases and How They Work”
Nitr ogen reduction to NH3 is a requisite transformation for life. Wh ile it is widely appreciated that the Fe-rich cofactors of nitrogenase enzy mes facilitate this transformation, how they do so remains poorly understoo d. A central element of debate has been the site(s) of dinitrogen coordinat ion and reduction. The synthetic inorganic community placed an early emphas is on Mo because Mo was thought to be an essential element of nitrogenases, and because pioneering work had established that well-defined Mo model com plexes could mediate the stoichiometric conversion of coordinated N2 sub> to NH3, ultimately leading to the development of catalytic systems.
It is known, however, that Fe is the only transition metal e ssential to all nitrogenases, and recent biochemical and spectroscopic data have implicated Fe as the likely site of N2 binding in FeMo-co. These observations motivated a search for functional Fe catalysts, example s of which were discovered by our lab several years ago. I will discuss our latest progress on Fe complexes that catalyze the reduction of N2 to NH3. Our most recent efforts have targeted improving the e fficiency of synthetic Fe nitrogenases via exploring alternative conditions and catalyst scaffolds, and using experiment and theory to better understa nd the mechanisms by which these Fe catalysts function. Our long-term goal is to use this understanding to couple solar water-splitting devices with a mmonia synthesis catalysts, akin to related approaches for the generation o f solar fuels.
~Coffee/tea will be served prior to l ecture~
X-ALT-DESC;FMTTYPE=text/html:“ i>Synthetic Single-Site Iron Nitrogenases and How They Work b>”
Nitrogen reduction to NH3 is a requisite transformation for life. While it is widely appreciated that the Fe-rich c ofactors of nitrogenase enzymes facilitate this transformation, how they do so remains poorly understood. A central element of debate has been the sit e(s) of dinitrogen coordination and reduction. The synthetic inorganic comm unity placed an early emphasis on Mo because Mo was thought to be an essent ial element of nitrogenases, and because pioneering work had established th at well-defined Mo model complexes could mediate the stoichiometric convers ion of coordinated N2 to NH3, ultimately leading to t he development of catalytic systems.
It is known, however, that Fe is the only transition metal essential to all nitrogenases, and recent bioche mical and spectroscopic data have implicated Fe as the likely site of N2 binding in FeMo-co. These observations motivated a search for func tional Fe catalysts, examples of which were discovered by our lab several y ears ago. I will discuss our latest progress on Fe complexes that catalyze the reduction of N2 to NH3. Our most recent efforts h ave targeted improving the efficiency of synthetic Fe nitrogenases via expl oring alternative conditions and catalyst scaffolds, and using experiment a nd theory to better understand the mechanisms by which these Fe catalysts f unction. Our long-term goal is to use this understanding to couple solar wa ter-splitting devices with ammonia synthesis catalysts, akin to related app roaches for the generation of solar fuels.
~Coffee/t ea will be served prior to lecture~
X-EXTRAINFO:Hosted by Chemistry G.S.O. DTSTAMP:20240329T095103 DTSTART:20190430T150000 DTEND:20190430T160000 SEQUENCE:0 TRANSP:OPAQUE END:VEVENT END:VCALENDAR