BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:5e11d7fa8c0df11201ecfc7c3b9531c5 CATEGORIES:Colloquium CREATED:20181213T195444 SUMMARY:Professor Tianning Diao, New York University LOCATION:CCB Auditorium DESCRIPTION:
“Stereoselect ive Alkene Carbofunctionalization via Radical Pathways”
Alken es are versatile functional groups that are employed in some of the most su ccessful asymmetric catalytic transformations. Enantioselective 1,2-dicarbo functionalization reactions of alkenes provides access to molecules with in tricate substitution patterns while introducing stereocenters. The new meth ods can be readily applied to prepare molecules with important bio-activity , such as a,a,b-triarylated ethane scaffolds. The use of reducing condition s with alkyl and aryl halides as the coupling partners avoids stoichiometri c organometallic reagents and tolerates a broad range of functional groups. Mechanistic studies, including kinetic studies and isolation of reaction i ntermediates, reveal that Ni catalysts initiate radical formation and lead to unconventional enantio-determining steps.
~ Coffe e/tea will be served prior to lecture~
X-ALT-DESC;FMTTYPE=text/html:“Stereoselective Alkene Carbofunctionalization via Radical P athways”
Alkenes are versatile functional groups that are emp loyed in some of the most successful asymmetric catalytic transformations. Enantioselective 1,2-dicarbofunctionalization reactions of alkenes provides access to molecules with intricate substitution patterns while introducing stereocenters. The new methods can be readily applied to prepare molecules with important bio-activity, such as a,a,b-triarylated ethane scaffolds. T he use of reducing conditions with alkyl and aryl halides as the coupling p artners avoids stoichiometric organometallic reagents and tolerates a broad range of functional groups. Mechanistic studies, including kinetic studies and isolation of reaction intermediates, reveal that Ni catalysts initiate radical formation and lead to unconventional enantio-determining steps.
~ Coffee/tea will be served prior to lecture ~
X-EXTRAINFO:Hosted by Professor Alan Goldman DTSTAMP:20240328T234931 DTSTART:20190507T150000 DTEND:20190507T160000 SEQUENCE:0 TRANSP:OPAQUE END:VEVENT END:VCALENDAR