BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:9611a06923fa8a8348f950364c014493 CATEGORIES:Seminar CREATED:20171130T131359 SUMMARY:Dr. Sarah Heissler LOCATION:WL 260 DESCRIPTION:Dr. Sarah HeisslerNational Institutes of HealthTuesday December 5, 2017\nWr ight Reiman Room 260 at 11:00 am\n"Looking Under The Hood of Myosin Motors" \nMyosin motors are powerful protein complexes that use the actin cytoskele ton as tracks to power a manifold of processes that produce force and movem ent in cells and organisms. My research aims to define the molecular basis and the regulation of myosin motors in physiological and pathological proce sses by probing their structure-function relationships. By applying sophist icated biochemical, biophysical, structural and cell biological methods and techniques, my research quantitatively describes the functional capacities and limitations of myosin motors in vitro. This knowledge can be applied i n a reductionist approach in single molecule assays to build a physiologica l process from its components parts in vitro to (i) characterize myosin mot or function in cells and organisms, (ii) reveal regulatory mechanisms of my osin motor function, and (iii) develop tools to manipulate myosin motor fun ction. By combining the power of in vitro and in vivo studies, my research contributes to the understanding of the physiological functions myosin moto rs play in health and disease and in the development of tools to study them .\n~Coffee/tea will be served prior to lecture~\n X-ALT-DESC;FMTTYPE=text/html:
Tuesday December 5, 2017
Wright Reiman Room 260 at 11:00 am
"Looking Under The Hood of Myosin Motors"
Myosin motors ar e powerful protein complexes that use the actin cytoskeleton as tracks to p ower a manifold of processes that produce force and movement in cells and o rganisms. My research aims to define the molecular basis and the regulation of myosin motors in physiological and pathological processes by probing th eir structure-function relationships. By applying sophisticated biochemical , biophysical, structural and cell biological methods and techniques, my re search quantitatively describes the functional capacities and limitations o f myosin motors in vitro. This knowledge can be applied in a reduc tionist approach in single molecule assays to build a physiological process from its components parts in vitro to (i) characterize myosin mot or function in cells and organisms, (ii) reveal regulatory mechanisms of my osin motor function, and (iii) develop tools to manipulate myosin motor fun ction. By combining the power of in vitro and in vivo stu dies, my research contributes to the understanding of the physiological fun ctions myosin motors play in health and disease and in the development of t ools to study them.
~Coffee/tea will be served prio r to lecture~
DTSTAMP:20240328T082844 DTSTART:20171205T160000 DTEND:20171205T170000 SEQUENCE:0 TRANSP:OPAQUE END:VEVENT END:VCALENDAR