Flow Technology: Towards Automated and On-Demand Synthesis
A survey conducted at Lonza indicated that 50% of the organic reactions would benefit from transferring from conventional batch synthesis to continuous production. Compared to batch or semibatch production, continuous production has the advantages of steady state operation, high heat and mass transfer rates, enhanced photon flux, reproducibility, and improved safety and process reliability. However, there are a lot of problems associated with continuous flow synthesis, such as difficult for parallel screening, handling of solid compounds, as well as incompatibility of reagents and solvents in streamlined multistep continuous-flow synthesis.
The research in Wu’s group focus on tacking those problems by designing novel advanced flow reactors, and utilizing them in synthesis of fine chemicals using inexpensive natural gases and hydrocarbons as feedstocks under visible-light irradiation. Compared to stepwise batch synthesis, multistep continuous flow synthesis enables the combination of multiple synthetic steps into a single and uninterrupted reactor network, thereby circumventing the need to isolate intermediates, and enabling automated synthesis. This talk will include the description of design of the “stop-flow micro-tubing” reactor and merging solid-phase synthesis and flow synthesis towards automated and on-demand synthesis of value-added functionalized organic molecules.
Hosted by Professor Jason Zhang