“Outer Membrane Protein Design Using Evolution and Experimentation”
Outer membrane proteins (OMPs) are the proteins in the surface of Gram-negative bacteria. These proteins have diverse functions but a single topology: the ?-barrel. I will discuss the evolutionary pathways and origins of this topology. The mechanisms of diversification have implications for antibiotic resistance, repeat protein biogenesis, and the nucleation of outer membrane protein folding. Furthermore, designing outer membrane proteins can be useful for disabling the efflux mechanism of antibiotic resistance.
~ Coffee/tea will be served prior to lecture~