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Professor Tianning Diao, New York University
Tuesday, May 07, 2019, 11:00am - 12:00pm

Diao Picture 3Stereoselective Alkene Carbofunctionalization via Radical Pathways”

Alkenes are versatile functional groups that are employed in some of the most successful asymmetric catalytic transformations. Enantioselective 1,2-dicarbofunctionalization reactions of alkenes provides access to molecules with intricate substitution patterns while introducing stereocenters. The new methods can be readily applied to prepare molecules with important bio-activity, such as a,a,b-triarylated ethane scaffolds. The use of reducing conditions with alkyl and aryl halides as the coupling partners avoids stoichiometric organometallic reagents and tolerates a broad range of functional groups. Mechanistic studies, including kinetic studies and isolation of reaction intermediates, reveal that Ni catalysts initiate radical formation and lead to unconventional enantio-determining steps.

~ Coffee/tea will be served prior to lecture~

Location CCB Auditorium
Hosted by Professor Alan Goldman