“Stereoselective Alkene Carbofunctionalization via Radical Pathways”
Alkenes are versatile functional groups that are employed in some of the most successful asymmetric catalytic transformations. Enantioselective 1,2-dicarbofunctionalization reactions of alkenes provides access to molecules with intricate substitution patterns while introducing stereocenters. The new methods can be readily applied to prepare molecules with important bio-activity, such as a,a,b-triarylated ethane scaffolds. The use of reducing conditions with alkyl and aryl halides as the coupling partners avoids stoichiometric organometallic reagents and tolerates a broad range of functional groups. Mechanistic studies, including kinetic studies and isolation of reaction intermediates, reveal that Ni catalysts initiate radical formation and lead to unconventional enantio-determining steps.
~ Coffee/tea will be served prior to lecture~