Course Descriptions

01:160:480 Structural Biology, Structural Biophysics, and Chemical Biology of Transcription (3 cr)
Transcription and transcriptional regulation. Structures and mechanisms of RNA polymerase, initiation factors, elongation factors, activators, repressors, promoters, and terminators. Protein-DNA interactions, protein-protein interactions, and use of energy to drive conformational changes and translocation. Emphasis on RNA polymerase as a molecular machine. Prerequisites: 01:160:305-306, 307-308, 315-316, or equivalent; 01:160:323-324, 327-328, 342, 11:115:409, 16:160:537, or equivalent (may be taken concurrently); 01:694:407-408, 11:115:403-404, 16:115:501-502, 511-512, and permission of the instructor.