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Picture courtesy of
Center for Molecular Biophysics |
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Richard D. Ludescher Our research is interested in molecular dynamics and the role it plays in mediating between the static structure and the dynamic function of proteins and other biomolecules. We use molecular fluorescence and phosphorescence to monitor molecular mobility in biomolecules on time scales ranging from picoseconds to seconds. We also seek to develop novel molecular probes and methods to monitor molecular mobility in solid biomaterials. We are currently interested in determining how the molecular mobility of proteins and carbohydrates in the amorphous solid state modulates the rates of chemical reaction and physical change. Current research focuses on how protein mobility modulates the rate of oxygen diffusion in amorphous films and on the development of phosphorescence techniques using, for example, tryptophan analogs to monitor specific modes of protein mobility in amorphous solids. The other topic area is the dynamics of proteins in the solid and dry states, the role that water plays in modulating these dynamics, and the possible dynamical transitions induced in these proteins by temperature. Current research focuses on how protein denaturation modulates the dynamics of dry proteins in powders and films and the development of novel optical luminescence techniques and novel probes (halogenated tryptophan analogs, for example) to monitor protein dynamics in the solid state.
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