47. Partha Ghosh, Joseph R. Cusick, Jennifer Inghrim and Lawrence J. Williams, Silyl-Substituted Spirodiepoxides: Stereoselective Formation and Regioselective Opening, Org. Lett., 2009, 11(20), 4672.
46. Yue Zhang, Joseph R. Cusick, Partha Ghosh, Ning Shangguan, Sreenivas Katukojvala, Jennifer Inghrim, Thomas J. Emge and Lawrence J. Williams, Spirodiepoxides: Synthesis of Epoxomicinoids, JOC, 2009, 74(20), 7707.
45. Partha Ghosh, Yue Zhang, Thomas J. Emge and Lawrence J. Williams, Modeling a Macrocyclic Bis[spirodiepoxide] Strategy to Erythronolide A, Org. Lett., 2009, 11(19), 4402.
44. Robert V. Kolakowski, Madhuri Manpadi, Yue Zhang, Thomas J. Emge and Lawrence J. Williams, Allene Synthesis via C−C Fragmentation: Method and Mechanistic Insight, JACS, 2009, 131, 12910.
43. Yue Zhang, Stephen D. Lotesta, Thomas J. Emge, Lawrence J. Williams, "Structure and reactivity of a chiral cyclononadienone", Tet. Lett, 2009, 10, 1882.
42. Gaojie Hu, Kai Liu, Lawrence J. Williams, "The Brosimum Allene: A Structural Revision", Org. Lett, 2008, 10, 5493.
41. Hiyun Kim, Lawrence J. Williams, "Recent Developments in Allene-based Synthetic Methods", Current Opinion in Drug Discovery & Development, 2008, 11(6),870.
40. Zhenghua Wang, Ning Shangguan, Joseph R. Cusick, Lawrence J. Williams, "Controlled Acid-Induced Rearrangement of a Spirodiepoxide", Synlett, 2008, 2,213.
39. Sezgin Kiren, Ning Shangguan, Lawrence J. Williams, "Direct Carbinolamide Synthesis", Tetrahedron Letters, 2007, 48, 7456.
38. Stephen D. Lotesta, Sezgin Kiren, Ronald R. Sauers, Lawrence J. Williams
, "Spirodiepoxides: Heterocycle Synthesis and Mechanistic Insight", Angewandte Chemie International Edition
,
2007,
46, 15.
37. Robert V. Kolakowski and Lawrence J. Williams, "Synthesis of the C21–C28 segment of pectenotoxin-4", Tetrahedron Letters, 2007, 48(27), 4761.
36. Shangguan, N.; Kiren, S.; Williams, L. J., "A Formal Synthesis of Psymberin", Org. Lett.; 2007; 9(6); 1093-1096.
35. Ghosh, P.; Lotesta, S. D.; Williams, L. J., "Spirodiepoxide Reaction with Cuprates", J. Am. Chem. Soc., 2007; 129(9); 2438-2439.
34. Lotesta, S. D.; Hou, Y.; Williams, L. J., "A Spirodiepoxide-Based Strategy to the A-B Ring System of Pectenotoxin 4", Org. Lett., 2007, 9(5), 869-872.
33. Kolakowski, R. V.; Shangguan, N.; Sauers, R. R.; Williams, L. J., "Mechanism of Thio Acid/Azide Amidation", J. Am. Chem. Soc., 2006, 128(17), 5695-5702.
32. Kristin N. Barlett, Robert V. Kolakowski, Sreenivas Katukojvala, and Lawrence J. Williams, "Thio Acid/Azide Amidation: An Improved Route to N-Acyl Sulfonamides", Org. Lett., 2006, 8(5), 823-826.
31. Robert V. Kolakowski, Ning Shangguan and Lawrence J. Williams, "Thioamides via thiatriazolines", Tetrahedron Lett., 2006, 47(7), 1163-1166.
31. Kiren, Sezgin; Williams, Lawrence J. "Configuration of the Psymberin Amide Side Chain", Org. Lett., 2005 7, 2905-2908.
30. S. Katukojvala, K. Barlett, S. Lotesta, L.J. Williams “Spirodiepoxides in Total Synthesis: Epoxomicin” J. Am. Chem. Soc. 2004 126, 15348-15349.
29. N. Shangguan, S. Katukojvala, L.J. Williams “The Reaction of Thioacids and Azides: A New Mechanism and New Applications” J. Am. Chem. Soc. 2003 125, 7754.
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28. G. Ragupathi, P. O. Livingston, C. Hood, J. Gathuru, S. E. Krown, P. B. Chapman, J.D. Wolchok, L.J. Williams, R. C. Oldrield, W. J. Hwu, “Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactone-keyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21” Clin. Cancer Res. 2003 9, 5214-5220.
26. Jagadish, B.; Carducci, M. D.; Bosshard, C.; Gunter, P.; Margolis, J. I.; Williams, L. J.; Mash, E. A. Cryst. Growth Des. 2003, 3, 811.
25. G. Ragupathi, D. M. Coltart, L. J. Williams, F. Koide, E. Kagan, J. Allen, C. Harris, P. W. Glunz, P. O. Livingston, S. J. Danishefsky “On the Power of Chemical Synthesis: Immunological Evaluation of Models for Multiantigenic Carbohydrate-Based Cancer Vaccines” Proc. Natl. Acad. Sci. USA 2002, 99, 13699.
24. D. M. Coltart, L. J. Williams, P. W. Glunz, D. Sames, S. D. Kuduk, J. Schwarz, X.-T. Chen, R. A. Kumar, S. J. Danishefsky, D. Live, “Principles of Mucin Architecture: Structural Studies on Synthetic Glycopeptides Bearing Clustered Mono-, Di-, Tri- and Hexasaccharide Glycodomains” J. Am. Chem. Soc. (2002) 124, 9833.
23. G. Ragupathi, P. P. Deshpande, D. M. Coltart, H. M. Kim, L. J. Williams, S. J. Danishefsky, P. O. Livingston "Constructing an adenocarcinoma vaccine: Immunization of mice with synthetic KH-1 nonasaccharide stimulates anti-KH-1 and anti-Ley antibodies" Int. J. Cancer, 2002, 99, 207.
22.T. Gilewski, G. Ragupathi, S. Bhuta, L. J. Williams, X.-F. Zhang, K. P. Bencsath, K. Panagea, J. Chin, L. Norton, A. Houghton, P. O. Livingston, S. J. Danishefsky "Vaccination of metastatic breast cancer patients with globo H keyhole limpet hemocyanin conjugate plus the immunological adjuvant QS21" Proc. Natl. Acad. Sci. USA 2001, 98, 3270.
21. V. Kudryshov, P. W. Glunz, L. J. Williams, S. Hintermann, S. J. Danishefsky, K. Lloyd "Epitope clustering, carrier structure, and adjuvant all influence antibody responses to Lewisy conjugates in mice. Implications for the design of carbohydrate-based cancer vaccines" Proc. Natl. Acad. Sci. USA 2001, 98, 3264.
20. Z. Wu, L. J. Williams, S. J. Danishefsky "A three step entry into the Aspirochlorine class of anti-fungal agents" Angew. Chem. Int. Ed. (2000) 39, 3866.
19. L. J. Williams, C. R. Harris, P. W. Glunz, S.J. Danishefsky "In Pursuit of an Anticancer Vaccine: A Monomolecular Construct Containing Multiple Carbohydrate Antigens" Tetrahedron Lett. (2000) 41, 9505.
18. B. Jagadish, L. J. Williams, M. D. Carducci, C. Bosshard, and Eugene A. Mash "Organic crystal engineering with piperazine-2,5-diones. 3. Crystal packing of a strongly dipolar piperazinedione" Tetrahedron Lett. (2000) 41, 9483.
17. P. W. Glunz, S. Hintermann, L. J. Williams, J. B. Schwarz, S. D. Kuduk, V. Kudryshov, K. O. Lloyd, S. J. Danishefsky, “Design and synthesis of Ley-bearing glycopeptides that mimic cell surface mucin glycoprotein architecture.” J. Am. Chem. Soc. (2000) 122, 7273.
16. L. J. Williams, R. M. Garbaccio, S. J. Danishefsky, "Iterative assembly of glycals and glycal derivatives: The synthesis of glycosylated natural products and complex oligosaccharides.” In Carbohydrates in Chemistry and Biology, B. Ernst, G. Hart, and P. Sinaÿ, Eds. Wiley-VCH Pub.: Weinheim, Germany (2000).
15. X. Wang, L. J. Williams, X.-F. Zhang, A. Zatorski, V. Kudryshov, G. Ragupathi, M. Spassova, W. Bornmann, S. F. Slovin, H. I. Scher, P. O. Livingston, K. Lloyd, S. J. Danishefsky, “Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: Isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens.” Proc. Natl. Acad. Sci. USA 2000, 97, 2719.
14. J. Allen, J. Allen, X.-F. Zhang, L. Williams, A. Zatorski, G. Ragupathi, P. O. Livingston, S. J. Danishefsky, “A second generation synthesis of the MBr1 (Globo-H) breast tumor antigen: New application of the n-pentenyl glycoside method for achieving complex carbohydrate protein linkages.” Chem. Eur. J. 2000, 6, 1366.
13. P. Glunz, S. Hintermann, J. Schwarz, S. Kuduk, X. Chen, L. Williams, D. Sames, S. J. Danishefsky, V. Kudryshov, K. Lloyd “Probing cell-surface ‘glyco-achitecture’ through total synthesis. Immunological consequences of a human blood group determinant in a clustered munic-like motif.” J. Am. Chem. Soc. 1999, 121, 10636.
12. D. H. Live, R. A. Kumar, L. J. Williams, D. Sames, “Insights into glycoproteins - A structural motif for mucins from a glycopeptide.” In Peptides for the New Millennium: Proceedings of the 16th American Peptide Symposium, G.B. Fields, J. P. Tam, and G. Barany, Eds. Kluwer Academic Pub., Dordecht, Holland (1999).
11. L. J. Williams, B. Jagadish, M. G. Lansdown, M. D. Carducci, E. A. Mash, “Organic crystal engineering with piperazine-2,5-diones. 2. Crystal packing of weakly dipolar piperazinediones derived from 2-amino-4-bromo-7-methoxyindan-2-carboxylic acids." Tetrahedron. 1999, 55, 14301.
10. L. J. Williams, B. Jagadish, S. R. Lyon, R. A. Kloster, M. D. Carducci, E. A. Mash, “Organic crystal engineering with piperazine-2,5-diones. 1. Crystal packing of piperazinediones derived from substituted 2-aminoindan-2-carboxylic acids." Tetrahedron 1999, 55, 14281.
9. D. Live, L. Williams, S. Kuduk, J. Schwarz, P. Glunz, X. -T. Chen, D. Sames, R. A. Kumar, S. J. Danishefsky, “Probing cell-surface architecture through synthesis: An NMR determined structural motif for tumor associated mucins.” Proc. Natl. Acad. Sci. USA, 1999, 96, 3489.
8. L. J. Williams, K. Kather, D. S. Kemp, “High helicities of Lys containing, Ala-rich peptides are primarily attributable to a large, context-dependent Lys stabilization.” J. Am. Chem. Soc. 1998, 120, 11033.
7. E. A. Mash, L. Williams, S. S. Pfeiffer, “Synthesis of Ethyl N-(diphenyl)methyl-1-2-3-4 tetrahydroisoquinoline-3-carboxylates.” Tetrahedron Letters 1997, 38, 6977.
6. E. A. Mash, L. Williams, “Engineering Molecular Solids.” Polymer Preprints 1996, 37, 207.
5. Danishefsky, S. J.; Sames, D.; Hintermann, S.; Chen, X. T.; Schwartz, J. B.; Glunz, P.; Ragupathi, G.; Livingston, P. O.; Kuduk S.; Lloyd, K. O.; Kudryashov, V.; Williams, L. J. Trimeric antigenic O-linked glycopeptide conjugates, methods of preparation and uses thereof. European Patent: WO9948515, 1999.
4. Danishefsky, S. J.; Lloyd, K. O.; Wang, Z.-G.; Williams, L. J. Affinity matrix bearing tumor-associated antigens. European Patent: WO0165261, 2001.
3. Danishefsky, S. J.; Sames, D.; Hintermann, S.; Chen, X. T.; Schwarz, J. B.; Glunz, P.; Ragupathi, G.; Livingston, P. O.; Kuduk, S.; Williams, L. J. α-O-linked glycoconjugates, methods of preparation and uses thereof. U.S. Patent 6,660,714, 2003.
2. Danishefsky, S. J.; Sames, D.; Hintermann, S.; Chen, X. T.; Schwarz, J. B.; Glunz, P.; Ragupathi, G.; Livingston, P. O.; Kuduk, S.; Williams, L. J. α-O-linked glycoconjugates, methods of preparation and uses thereof. U.S. Patent 7,160,856, 2007.
1. Danishefsky, S. J.; Allen, J. R.; Ragupathi, G.; Livingston, P. O.; Williams, L. J. Novel glycoconjugates, glycoamino, acids, intermediates thereto, and uses thereof. European Patent: DE60027905T, 2007.