CCB Colloquium presentation by Dr. Till Opatz, University of Mainz.
Host: Kai Hultzsch
Title: From Deprotonated Aminonitriles to Bioactive Natural Products
The strong anion stabilizing capacity of the nitrile group permits a-aminonitriles with a primary or secondary amino group to be used as readily available a-aminocarbanion equivalents upon deprotonation with a suitable base. These agents can serve as building blocks for the construction of highly substituted amines and N-heterocycles which are obtained in very short reaction sequences or one-pot procedures.
Another aspect of our current work is the chemistry of natural products which we investigate in close collaboration with the Institute of Biotechnology and Drug Research in Kaiserslautern, Germany.
In the past years, we have elucidated the structures of several hundred secondary metabolites from higher fungi and terrestrial plants which have shown biological activity in screening campaigns. In addition, we are interested in the total synthesis of bioactive natural products and their analogues.
Key References: PDF files attached