 |
 |
Chemistry & Chemical Biology / New Brunswick |
Faculty and Staff
Directory of People
- View faculty members by
- Alphabetical Listing
- Research Interests
- Departmental Divisions
View: All | Faculty | Administrative | Department Staff
Grad Students | Instructional Staff | Retired Faculty
Research Professors | Post-Docs | Research Staff
| Roger A. Jones Professor and Chair B.S. 1969, Delaware Ph.D. 1974, Alberta |
|||||
|
Research
Summary
My research interests are in nucleic acid synthetic chemistry, structure, and interactions. We are interested in new methods for nucleoside and nucleic acid synthesis, both for DNA and RNA fragments. In particular, we work to develop synthetic approaches to nucleoside derivatives of biological importance and nucleosides containing stable isotopes such as 2H, 13C, or 15N, for incorporation into nucleic acids. These molecules probe the basis of the interrelation of sequence, specific structural features, and the stability and conformational properties of both DNA and RNA.The Jones research group
Awards & Honors
Representative Publications
Han, Q.; Gaffney, B.; Jones, R.A. “One-Flask Synthesis of Dinucleoside Tetra- and Pentaphosphates,” Organic Letters, 2006, 8, 2075-2077.
Fan, Y., Gaffney, B., Jones, R.A. “RNA GG·UU Motif Binds K+ but Not Mg2+,” J. Am. Chem. Soc., 2005, 127, 17588-17589.
Zhang, Z., Gaffney, B., Jones, R.A “c-di-GMP Displays a Monovalent Metal Ion-Dependent Polymorphism,” J. Am. Chem. Soc., 2004, 126, 16700-16701.
Wang, G., Gaffney, B., Jones, R.A. “Differential Binding of Mg2+, Zn2+, and Cd2+ at Two Sites in a Hammerhead Ribozyme Motif, Determined by 15N NMR,” J. Am. Chem. Soc., 2004, 126, 8908-8909.
Fan, Y., Gaffney, B., Jones, R.A. “Transient Silylation of the Guanosine O6 and Amino Groups Facilitates N-Acylation,” Organic Letters, 2004, 6, 2555-2557.
Kettani, A.; Gorin, A.; Majumdar, A.; Hermann, T.; Skripkin, E.; Zhao, H.; Jones, R. A.; Patel, D. J.; “A Dimeric DNA Interface Stabilized Ao(GoGoGoG)oA Hexads and Bound Monovalent Cations,” J. Mol. Biol. 2000, 297, 627-644.
Kuryavyi, V.; Kettani, A.; Wang, W.; Jones, R. A.; Patel, D. J. “A Diamond-shaped Zipper-like DNA Architecture Containing Triads Sandwiched between Mismatches and Tetrads,” J. Mol. Biol. 2000, 295, 455-469.
Veldhuyzen, W. F.; Shallop, A. J.; Jones, R. A.; Rokita, S. E. “Thermodynamic versus Kinetic Products of DNA Alkylation as Modeled by Reaction of Deoxyadenosine,” J. Am. Chem. Soc., in press.
Kettani, A.; Bouaziz, S.; Skripkin. E.; Majumdar, A.; Wang, W.; Jones, R. A.; Patel, D. J. “Interlocked mismatch-aligned arrowhead DNA motifs,” Structure, 1999, 7, 803-815.
Lorigan, G. A.; McNamara, R.; Jones, R. A.; Opella, S. J. “Magnitudes and Orientations of the 15N Chemical Shift Tensor of [1-15N]-2-Deoxyguanosine Determined on a Polycrystalline Sample by Two-Dimensional Solid-State NMR Spectroscopy,” J. Mag. Res. 1999, 140, 315-319.
Wang, W.; Song, Q.; Jones, R. A. “Nucleoside Recovery in DNA and RNA Synthesis,” Tetrahedron Letters, 1999, 40, 8971-8974.
Zhang, X.; Gaffney, B. L.; Jones, R. A. “15N NMR of RNA Fragments Containing Specifically Labeled GU and GC Pairs,” J. Am. Chem. Soc. 1998, 120, 615-618.
Zhao, H.; Pagano, A. R.; Wang, W.; Shallop, A.; Gaffney, B. L.; Jones, R. A. “Use of a 13C Atom to Differentiate Two 15N-labeled Nucleosides. Syntheses of [15NH2]-Adenosine; [1,NH2-15N2]- and [2-13C-1,NH2-15N2-]-Guanosine; [1,7,NH2-15N3]- and [2-13C-1,7,NH2-15N3]-2-Deoxyguanosine,” J. Org. Chem. 1998, 22, 7832-7835.
Kettani, A.; Bouaziz, S.; Gorin, A.; Zhao, H.; Jones, R. A.; Patel, D. J. “Solution structure of a Na cation stabilized DNA quadruplex containing G•G•G•G and G•C•G•C tetrads formed by G-G-G-C repeats observed in adeno-associated viral DNA,” J. Mol. Biol. 1998, 282, 619-636.
Abad, J.-L.; Shallop, A. J.; Gaffney, B. L.; Jones, R. A. “Use of 13C tags with specifically 15N-Labeled DNA and RNA,” Biopolymers Nucleic Acid Sciences, 1998, 48, 57-64.
Song, Q.; Wang, W.; Fischer, A.; Zhang, X.; Gaffney, B. L.; Jones, R. A. “High yield protection of purine ribonucleosides for phosphoramidite RNA synthesis,” Tetrahedron Letters, 1999, 40, 4153-4156.
Song, Q. and Jones, R. A. “Use of silyl ethers as fluoride scavengers in RNA synthesis,” Tetrahedron Letters, 1999, 40, 4653-4654.
Abad, J-L; Gaffney, B. L.; Jones, R. A. “15N Multilabeled Adenine and Guanine Nucleosides. Syntheses of [1,3,NH2-15N3]- and [2-13C-1,3,NH2-15N3]-Adenosine, –Guanosine, -2-Deoxyadenosine, and -2-Deoxyguanosine,” J. Org. Chem.1999, 64, 6575-6582.
Wang, W.; Song, Q.; Jones, R. A. “Nucleoside Recovery in DNA and RNA Synthesis,” Tetrahedron Letters, in press.
Kettani, A.; Bouaziz, S.; Skripkin. E.; Majumdar, A.; Wang, W.; Jones, R. A.; Patel, D. J. “Interlocked mismatch-aligned arrowhead DNA motifs,” Structure, 1999, 7, 803-815.
Lin, C.; Wang, W.; Jones, R. A.; Patel, D. J. “Formation of an amino-acid-binding pocket through adaptive zippering-up of a large DNA hairpin loop,” Chemistry & Biology 1998, 5, 555-572.
Zhang, X.; Gaffney, B. L.; Jones, R. A. “15N NMR of a Specifically Labeled RNA Fragment Containing Intrahelical GU Wobble Pairs,” J. Am. Chem. Soc. 1997, 119, 6432-6433.
Mazumder, A.; Uchida, H.; Neamati, N.; Sunder, S.; Jaworskamaslanka, M.; Wickstrom, E.; Zeng, F.; Jones, R. A.; Mandes, R. F.; Chenault, H. K.; Pommier, Y. “Probing Interactions Between Viral DNA and Human Immunodeficiency Virus Type 1 Integrase Using Dinucleotides,” Mol. Pharmacology 1997, 51, 567-575.
Zhang, X.; Gaffney, B. L.; Jones, R. A. “RNA Synthesis using a Universal, Base-Stable Allyl Linker,” Nucleic Acids Res. 1997, 25, 3980-3983.
Zhang, X.; Abad, J-L.; Huang, Q.; Zeng, F.; Gaffney, B. L.; Jones, R. A. “High Yield Protection of Purine Ribonucleosides for H-Phosphonate RNA Synthesis,” Tetrahedron Lett. 1997, 41, 7135-7138.