February 27, 2015 - 3:30pm
Wright Rieman, Rm. 260
"Direct Catalytic Synthesis of Tetrasubstituted Carbons Bearing Amines and Heteroaromatics"
Spring 2015 Organic Seminar Series
|Speaker: Catharine Larsen
|Abstract: The direct formation of tetrasubstituted carbons bearing amines is rare—especially compared to the wide array of trisubstituted products accessible from multicomponent couplings of aldehydes, amines, and nucleophiles. Dual copper/titanium catalysis is required to overcome the barrier to condensation of a ketone with an amine and subsequent alkynylation, and copper-catalyzed Markovnikov alkyne hydroamination provides a unique alternate pathway to tetrasubstituted propargylamines. In addition, green solvent-free conditions provide one-step syntheses of alkyl- and pyridyl-substituted quinolines.|
|Host: Professor Daniel Seidel|
|~ Coffee/tea will be served prior to lecture ~|