Catharine Larsen

Schedule: 
February 27, 2015 - 3:30pm
Location: 
Wright Rieman, Rm. 260
Type: 
Organic Seminar

"Direct Catalytic Synthesis of Tetrasubstituted Carbons Bearing Amines and Heteroaromatics"

Spring 2015 Organic Seminar Series

Speaker: Catharine Larsen
Chemistry Department
UC Riverside
Abstract: The direct formation of tetrasubstituted carbons bearing amines is rareā€”especially compared to the wide array of trisubstituted products accessible from multicomponent couplings of aldehydes, amines, and nucleophiles. Dual copper/titanium catalysis is required to overcome the barrier to condensation of a ketone with an amine and subsequent alkynylation, and copper-catalyzed Markovnikov alkyne hydroamination provides a unique alternate pathway to tetrasubstituted propargylamines. In addition, green solvent-free conditions provide one-step syntheses of alkyl- and pyridyl-substituted quinolines.
Poster: PDF
Host: Professor Daniel Seidel
~ Coffee/tea will be served prior to lecture ~