Brandon Ashfeld

Schedule: 
March 12, 2013 - 7:00am
Location: 
Wright Rieman Auditorium
Type: 
Colloquium

 

CHEMISTRY AND CHEMICAL BIOLOGY
SPRING 2013 COLLOQUIUM

Tuesday, March 12

11:00am

Wright-Rieman Auditorium
 Busch Campus

Brandon Ashfeld

University of Notre Dame


Exploring Unconventional Carbonyl Reactivity for Natural
Products and Designed Materials Synthesis

Carbonyl functionalization is central to the development of many classic and newly designed synthetic methods. By exploiting the inherent reactivity of carbonyl derivatives, the synthesis of biologically active natural products and materials designed for gas phase carbon separation are highlighted by the development of unconventional carbon-heteroatom and carbon-carbon bond-forming enabling methods. Our program is focused on the design and development of 1) N-heterocyclic materials for the energy efficient gas phase separation of CO2, 2) phosphorus-mediated, chemoselective C-C and C-N bond formations, and 3) a the titanocene-catalyzed functionalization of aldehydes as a traceless dielectrophilic functional group. Our overall objective is to develop new chemical constructs that will enable the discovery of improved chemotherapies for brain and nervous system cancers, and materials for the reduction of atmospheric concentrations of anthropogenic CO2.

~Coffee/tea will be served prior to lecture~

Host:  Daniel Seidel

Anyone wishing to meet with Prof. Ashfeld, please contact Daniel Seidel at 732-445-6921 or by email at seidel@rutchem.rutgers.edu to set up an appointment time.

 

References:

Gianino, J. B.; Ashfeld, B. L., "Titanocene-Catalyzed Multicomponent Coupling Approach To Diarylethynyl Methanes." J. Am. Chem. Soc., 2012, 134 (44), 18217-18220. 

Kosal, A. D.; Wilson, E. E.; Ashfeld, B. L., "Phosphine-Based Redox Catalysis in the Direct Traceless Staudinger Ligation of Carboxylic Acids and Azides." Angew. Chem. Int. Ed., 2012, 51 (48), 12036-12040.