Biodegradable Ferulic Acid-containing Poly(anhydride-ester): Degradation Products with Controlled Release and Sustained Antioxidant Activity

Ferulic acid is a naturally-ocurring antioxidant and antimicrobial compound used in biomedical and cosmetic formulations to prevent oxidative stress and aging, but suffers from poor stability.  To improve stability, ferulic acid was chemically incorporated into a poly(anhydride-ester) backbone that subsequently exhibited controlled, sustained release of the bioactive upon hydrolytic degradation.

Publication: 

Ouimet, MA; Griffin, J; Carbone-Howell, AL; Wu, WH; Stebbins, ND; Di, R; Uhrich, KE “Biodegradable Ferulic Acid-containing Poly(anhydride-ester): Degradation Products with Controlled Release and Sustained Antioxidant Activity”, Biomacromolecules 14 (3) 854-861 (2013).  10.1021/bm3018998 PMID: 23327626  PMCID: PMC3595371

Group Members: 

Nicholas D. Stebbins
PhD Candidate, Dr. Kathryn Uhrich Research Group

Year of Research Highlight: 
2013